General description
A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7275.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
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